Open AccessEffect of CPT‐11 on Lipid Peroxide Level in Mouse Tissues
Author(s) -
Sadzuka Yasuyuki,
Hirota Sadao
Publication year - 1997
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1997.tb00411.x
Subject(s) - lipid peroxide , peroxide , chemistry , biochemistry , medicine , lipid peroxidation , oxidative stress , organic chemistry
We examined the effects of CPT‐11 on lipid peroxide level and glutathione peroxidase (GSHpx) activity as indices of the toxicity of this antitumor agent in mouse and rat tissues. After CPT‐11 (100 mg/kg, i.p.) administration, the lipid peroxide level in the heart increased 1.5 fold (mice) and 1.3 fold (rats) over the control levels. GSHpx activity decreased to 64% of the control. In the lung, the lipid peroxide level and GSHpx activity increased 2.5 fold and decreased to 74% after CPT‐11 administration, respectively, compared with the control values. These results suggested that CPT‐11 may cause cardiotoxicity and pulmotoxicity. In rat hone marrow, the lipid peroxide level increased on the 2nd day after CPT‐11 injection. We suggest that in both single and combination treatment with CPT‐11, the possibility of side effects should be taken into consideration.