Open AccessExpression of Interstitial Collagenase (Matrix Metalloproteinase‐1) in Gastric Cancers
Author(s) -
Sakurai Yoshihiko,
Otani Yoshihide,
Kameyama Kaori,
Hosoda Yasuhiro,
Okazaki Isao,
Kubota Tetsuro,
Kumai Koichiro,
Kitajima Masaki
Publication year - 1997
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1997.tb00396.x
Subject(s) - interstitial collagenase , pathology , stromal cell , immunostaining , in situ hybridization , matrix metalloproteinase , immunohistochemistry , biology , infiltration (hvac) , gene expression , collagenase , stroma , metastasis , metalloproteinase , cancer research , cancer , medicine , gene , enzyme , biochemistry , physics , genetics , thermodynamics
The expression of matrix metalloproteinase‐1 (MMP‐1) gene and the presence of MMP‐1 protein in gastric cancer were examined by in situ hybridization and immunohistochemistry. Expression of the interstitial Collagenase (MMP‐1) gene was detected within the stroma of the neoplastic glands, and infiltration of eosinopilic was observed to be associated with regions of MMP‐1 gene expression. The degree of eosinophils infiltration correlated with the level of MMP‐1 mRNA expression. Immunostaining showed localization of MMP‐1 protein in the stromal cells, and additionally in the neoplastic glands. These findings indicate that the stromal cells may play an important role in the expression of MMP‐1, and suggest a pathophysiological role for MMP‐1 in the invasion and metastasis of gastric cancer.