Open AccessAlternative Splicing of the FHIT Gene in Colorectal Cancers
Author(s) -
Hibi Kenji,
Taguchi Masumi,
Nakamura Hajime,
Hirai Atsushi,
Fujikake Yoshihiro,
Matsui Takanori,
Kasai Yasushi,
Akiyama Seiji,
Ito Katsuki,
Takagi Hiroshi
Publication year - 1997
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1997.tb00393.x
Subject(s) - exon , colorectal cancer , colorectal adenoma , rectum , alternative splicing , fhit , gene product , adenoma , cancer research , rna splicing , gene , medicine , biology , oncology , cancer , genetics , tumor suppressor gene , carcinogenesis , gene expression , rna
In the present study, we examined the status of the FHIT gene in 112 colorectal cancer and 137 colorectal adenoma specimens. In a total of 5 specimens (4 colorectal cancers and 1 colorectal adenoma), a common smaller product was detected in addition to the normal size product. This smaller product had lost exon 4, the 5′ noncoding region of the FHIT gene, owing to alternative splicing. Moreover, all of the 5 tumors with alternative splicing were located lower on the rectum than the anterior peritoneal reflection.