Open AccessDevelopment of Aberrant Crypt Foci Involves a Fission Mechanism as Revealed by Isolation of Aberrant Crypts
Author(s) -
Fujimitsu Yasunobu,
Nakanishi Hayao,
Inada Kenichi,
Yamachika Takasuke,
Ichinose Masutaro,
Fukami Hiroko,
Tatematsu Masae
Publication year - 1996
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1996.tb03133.x
Subject(s) - crypt , aberrant crypt foci , fission , biology , cell division , microbiology and biotechnology , pathology , anatomy , genetics , medicine , physics , cell , colorectal cancer , endocrinology , colonic disease , cancer , quantum mechanics , neutron
Morphological analysis of isolated colonic crypts in rats, postnatally, indicated that the crypts reproduce themselves by a fission mechanism, the division beginning at the crypt base and proceeding upwards until there are two separate crypts. Occasionally, before the separation is complete, a second fission process starts on one or both sides of a bifurcating crypt and a triple‐branched or quadruple‐branched crypt results. Analysis of isolated aberrant crypt foci (ACF) in rats treated with 1,2‐dimethylhydrazine revealed that the development of ACF consisting of multiple crypts is also due to a fission mechanism. Initially, an indentation appears at the base of a single ACF crypt, with subsequent formation of a bifurcation and eventual crypt division.