Open Accessp53 Mutations in Two Patients with Intraductal Papillary Adenoma of the Pancreas
Author(s) -
Kaino Miyuki,
Kondoh Satoshi,
Okita Satoshi,
Ryozawa Syomei,
Hatano Satoko,
Shiraishi Kei,
Kaino Seiji,
Akiyama Tetsuji,
Okita Kiwamu,
Kawano Toyokazu
Publication year - 1996
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1996.tb03132.x
Subject(s) - pancreas , adenoma , medicine , pathology , pancreatic disease , gastroenterology , cancer research
There has been no report on p53 gene mutation in benign human pancreatic intraductal tumors. We examined pancreatic juice and tissue specimens from two patients with intraductal papillary adenoma of the pancreas by polymerase chain reaction‐single‐strand conformation polymorphism analysis and direct sequencing and found point mutations of p53 gene resulting in amino acid substitutions in exons 6 and 8. Thus, p53 gene mutation may be an early event in the neoplastic process of some pancreatic intraductal tumors and may play an important role in tumorigenesis.