Open AccessGenetic Controls of Susceptibility and Resistance to 4‐Nitroquinoline 1‐Oxide‐induced Tongue Carcinomas in Rats
Author(s) -
Kitano Motoo,
Hirayama Yoshikazu,
Tanuma Junichi,
Matsuuchi Hiroaki,
Miura Yoshihiro,
Li TieJun,
Semba Ichiro,
Ozaki Hiroki S.,
Kokubu Teiji,
Hatano Hiromichi,
Tada Mariko,
Kobayashi Yasuto,
Shisa Hayase
Publication year - 1996
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1996.tb03116.x
Subject(s) - 4 nitroquinoline 1 oxide , incidence (geometry) , hybrid , tongue , biology , oral administration , medicine , gene , endocrinology , genetics , pathology , carcinogenesis , botany , physics , optics
We analyzed the incidence of infiltrative mass‐type tongue carcinomas (IMTC) induced in 550 rats by continuous oral administration of 0.001% 4‐nitroquinoline 1‐oxide solution for 180 days. The study included various crosses of susceptible Dark‐Agouti rats (DA) and resistant Wistar/Furth rats (WF). DA showed a 93.6% incidence of IMTC measuring more than 5 mm in their largest diameter, while WF showed only a 4% incidence. Reciprocal F 1 and F 2 hybrids mated by DA and WF showed 47.5% and 45.8% incidences, respectively. Meanwhile, reciprocal backcrossed hybrids to DA and WF showed 73.7%, and 24.6% incidences, respectively. Segregation of the incidences suggests that there are two autosomal dominant genes, one linked to the susceptibility of DA and the other to the resistance of WF.