Open AccessSelective Reduction in α‐Hydroxypalmitic Acid‐containing Sphingomyelin and Concurrent Increase in Hydroxylated Ceramides in Murine Skin Tumors Induced by an Initiation‐promotion Regimen
Author(s) -
Kitano Yukie,
Iwamori Yuriko,
Kiguchi Kaoru,
DiGiovanni John,
Takahashi Toshie,
Kasama Kenji,
Niwa Takashi,
Harii Kiyonori,
Iwamori Masao
Publication year - 1996
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1996.tb00243.x
Subject(s) - sphingomyelin , sphingomyelin phosphodiesterase , ceramide , sphingosine , chemistry , fatty acid , sphingolipid , tumor promotion , epidermis (zoology) , biochemistry , carcinogenesis , cholesterol , biology , apoptosis , receptor , anatomy , gene
The sphingomyelin cycle is activated to accumulate ceramides in the process of epidermal differentiation. We found that sphingomyelin in the epidermis of 4 different murine strains gave three bands on TLC, the lower band containing α‐hydroxypalmitic acid (C16h:0(α)). However, in the papillomas induced in the skin of SENCAR and SSIN mice by initiation with 7,12‐dimethylbenz[α] anthracene followed by promotion with 12‐ O ‐tetradecanoylphorbol acetate, the concentration of C16h:0(α)‐ containing sphingomyelin was selectively diminished with a concomitant increase in the concentrations of the ceramides containing α‐hydroxy fatty acids. These findings indicate a possible involvement of the selective hydrolysis of α‐hydroxy fatty acid‐containing sphingomyelin in the process of tumorigenesis in mouse skin.