Open AccessNon‐invasive Characterization of Brain Tumor by in‐vivo Proton Magnetic Resonance Spectroscopy
Author(s) -
Harada Masafumi,
Tanouchi Miki,
Nishitani Hiromu,
Miyoshi Hirokazu,
Bandou Kazuhiko,
Kannuki Seiji
Publication year - 1995
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1995.tb03059.x
Subject(s) - ependymoma , astrocytoma , phosphocreatine , glioma , creatine , proton magnetic resonance , in vivo , choline , meningioma , brain tumor , magnetic resonance imaging , pathology , nuclear magnetic resonance , medicine , oligodendroglioma , nuclear magnetic resonance spectroscopy , in vivo magnetic resonance spectroscopy , chemistry , biology , radiology , cancer research , physics , microbiology and biotechnology , energy metabolism
We studied the feasibility of characterizing brain tumor tissue by localized proton magnetic resonance spectroscopy ( 1 H‐MRS), Twenty‐six newly diagnosed tumors were examined by in‐vivo , 1 H‐MRS. The NAA (N‐acetylaspartate)/Cho (choline) ratio of Grade 2 astrocytoma was higher than that of Grade 4. The Cho/Cr (creatine and phosphocreatine) ratio of meningioma was considerably higher than that of glioma of all grades. We have experienced only two cases of ependymoma and the Cho/Cr ratios of both were lower than that of glioma. It seems likely that 1 H‐MRS can be used to differentiate Grade 2 from Grade 4 in most cases of astrocytoma based on the NAA/Cho ratio, though a few cases will overlap. Meningioma can be distingulshed easily from glioma, and the results of our study suggest that ependymoma shows a characteristic pattern on 1 H‐MRS, different from those of other brain tumors.