Open AccessPrognostic Value of p53 Protein Accumulation in Cancer Cell Nuclei in Adenocarcinoma of the Uterine Cervix
Author(s) -
Tsuda Hitoshi,
Jiko Kumiko,
Tsugane Shoichiro,
Yajima Masazumi,
Yamada Takuro,
Tanemura Kenjiro,
Tsunematsu Ryuichiro,
Ohmi Kazuo,
Sonoda Takahiko,
Hirohashi Setsuo
Publication year - 1995
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1995.tb03019.x
Subject(s) - nuclear atypia , cervix , adenocarcinoma , pathology , cancer , incidence (geometry) , biopsy , medicine , atypia , oncology , biology , cancer research , immunohistochemistry , physics , optics
Adenocarcinoma of the uterine cervix (CxAd) is one of the most distressing malignancies of the female reproductive system because of its tendency to spread aggressively and to be resistant to radiation and systemic therapies. To clarify the prognostic significance of p53 alteration in CxAd, we immunohistochemically examined the incidence of p53 nuclear accumulation, which is considered to be mostly parallel with p53 gene mutation, and its association with clinicopathological parameters in 26 patients with CxAd. The overall incidence of p53 nuclear accumulation was 46% (12 of 26), being higher in groups with clinically advanced disease, higher degrees of cellular atypia, and deeper myometrial invasion, but significantly lower in patients with integration of human papillomavirus (HPV) type 16 or 18 DNA. Nuclear p53 immunoreactivity as well as lymph node status, depth of invasion and the absence of HPV‐DNA integration were significant indicators of a poor prognosis. Examination of p53 nuclear accumulation could be applied to biopsy material, and would be of practical assistance in predicting the prognosis of CxAd both preoperatively and postoperatively.