Open AccessOvarian Teratomas in Mice Lacking the Protooncogene c‐mos
Author(s) -
Furuta Yasuhide,
Shigetani Yasuyo,
Takeda Naoki,
Iwasaki Kuniko,
Ikawa Yoji,
Aizawa Shinichi
Publication year - 1995
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1995.tb02432.x
Subject(s) - teratoma , ovarian teratoma , biology , parthenogenesis , germ cell tumors , embryo , metastasis , embryonic stem cell , pathology , teratocarcinoma , germ cell , cancer research , ovary , endocrinology , cellular differentiation , medicine , microbiology and biotechnology , genetics , cancer , chemotherapy , gene
Parthenogenesis has been suggested to be tightly coupled with development of ovarian teratomas. Indeed, ovarian tumors developed in c‐mos ‐delieicnt female mice, which are characterized by the parthenogenetic activation of oocytes. The tumors appeared at a frequency of 30% between 4 and 8 months of age, and did not develop in younger or older mice. Most of the tumors were benign and consisted of multi‐focal cysts most notably with mature ectodermal components, but also with mesodermal and endodermal components. One among 17 tumors observed consisted of extraembryonic tissues alone, and two bore malignant components with metastasis to peritoneal organs. The results strongly suggest the involvement of c‐mos mutations in human germ cell tumors.