Establishment of a Human Small Cell Lung Cancer Cell Line Producing a Large Amount of Anti‐diuretic Hormone | Zendy

Terasaki Takeo | Zendy; Matsuno Yoshihiro | Zendy; Shimosato Yukio | Zendy; Yamaguchi Ken | Zendy; Ichinose Hiroshi | Zendy; Nagatsu Toshiharu | Zendy; Kato Kanefusa | Zendy

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Establishment of a Human Small Cell Lung Cancer Cell Line Producing a Large Amount of Anti‐diuretic Hormone

Author(s) -

Terasaki Takeo,

Matsuno Yoshihiro,

Shimosato Yukio,

Yamaguchi Ken,

Ichinose Hiroshi,

Nagatsu Toshiharu,

Kato Kanefusa

Publication year - 1994

Publication title -

japanese journal of cancer research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.035

H-Index - 141

eISSN - 1349-7006

pISSN - 0910-5050

DOI - 10.1111/j.1349-7006.1994.tb02420.x

Subject(s) - diuretic , hormone , cell culture , endocrinology , secretion , medicine , lung cancer , cell , cancer , biology , biochemistry , genetics

A new cancer cell line (Lu‐165) producing a large amount of anti‐diuretic hormone (ADH, 2.8 μg/g protein) was established from a 50‐year‐old small cell lung cancer patient presenting with a syndrome of inappropriate anti‐diuretic hormone secretion. These cells grew well in serum‐supplemented medium and during more than 100 passages they continued producing a large amount of this hormone. This cell line will be a useful tool for studies of the biochemistry and pathology of ADH‐producing cancer.

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