Open AccessEstablishment of a Human Small Cell Lung Cancer Cell Line Producing a Large Amount of Anti‐diuretic Hormone
Author(s) -
Terasaki Takeo,
Matsuno Yoshihiro,
Shimosato Yukio,
Yamaguchi Ken,
Ichinose Hiroshi,
Nagatsu Toshiharu,
Kato Kanefusa
Publication year - 1994
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1994.tb02420.x
Subject(s) - diuretic , hormone , cell culture , endocrinology , secretion , medicine , lung cancer , cell , cancer , biology , biochemistry , genetics
A new cancer cell line (Lu‐165) producing a large amount of anti‐diuretic hormone (ADH, 2.8 μg/g protein) was established from a 50‐year‐old small cell lung cancer patient presenting with a syndrome of inappropriate anti‐diuretic hormone secretion. These cells grew well in serum‐supplemented medium and during more than 100 passages they continued producing a large amount of this hormone. This cell line will be a useful tool for studies of the biochemistry and pathology of ADH‐producing cancer.