Open AccessTelomere Reduction of Specific Chromosome Translocation in Acute Myelocytic Leukemia
Author(s) -
Takauchi Katsuhiko,
Tashiro Satoshi,
Ohtaki Megu,
Kamada Nanao
Publication year - 1994
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1994.tb02071.x
Subject(s) - chromosomal translocation , karyotype , myelocytic leukemia , telomere , biology , microbiology and biotechnology , leukemia , cytogenetics , chromosome , immunology , genetics , dna , gene
The length of telomere restriction fragments (TRF) was studied by Southern blotting in 42 patients with acute myelocytic leukemia (AML) including 15 patients with 8;21 translocation, 8 with 15;17 translocation and 19 with a normal karyotype. The TRF length of leukemic cells with a normal karyotype and with 8;21 or 15;17 translocation showed significant reduction compared to that of lymphocytes from normal individuals (P<0.05). In addition, there was a statistically significant difference in TRF length between leukemic cells with a normal karyotype and 8;21 translocation (P<0.05). Therefore, the significant difference of telomere reduction in 8;21 translocation may be an important factor in the leukemogenic process.