Open AccessAlterations of Integrin Expression in Human Lung Cancer
Author(s) -
Suzuki Susumu,
Takahashi Takashi,
Nakamura Shigeo,
Koike Koichi,
Ariyoshi Yutaka,
Takahashi Toshitada,
Ueda Ryuzo
Publication year - 1993
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1993.tb02851.x
Subject(s) - integrin , lung cancer , metastasis , cancer research , biology , cancer , cell , cell adhesion , extracellular matrix , collagen receptor , cancer cell , pathology , immunology , microbiology and biotechnology , medicine , biochemistry , genetics
Integrins are cell‐surface receptors which are involved in cell‐matrix and/or cell‐cell adhesion. They have been suggested to play a role in tumor invasion and metastasis. We examined the expression of various integrin subunits in normal and cancer cells of the lung using 33 human lung cancer cell lines as well as 6 lung cancer samples from which tumor cell lines could be established. This study clearly demonstrated that changes in the expression of certain integrins occur frequently in lung cancer, especially in small cell lung cancer. Loss of the α1 subunit of the β 1 integrin family appears to be the most prominent change, although loss of other integrin subunits such as α 2 or emergence of some integrin subunits such as α v can also be observed. These results suggest that changes in integrin expression may contribute to the invasive and/or metastatic behavior of lung cancer.