Open AccessNeutralizing Antibody to Vesicular Stomatitis Virus (HTLV‐I) Pseudotype in Infants Born to Seropositive Mothers
Author(s) -
Iwahara Yoshihito,
Sawada Takashi,
Taguchi Hirokuni,
Hoshino Hiroo,
Umemoto Masakazu,
Take Hiromichi,
Foung Steven,
Miyoshi Isao
Publication year - 1993
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1993.tb02842.x
Subject(s) - virology , vesicular stomatitis virus , neutralizing antibody , antibody , virus , stomatitis , breast feeding , titer , medicine , immunization , immunology , vesicular stomatitis , vesicular stomatitis indiana virus , antibody titer , biology , pediatrics
Breast feeding is the major route of mother‐to‐child transmission of human T‐cell leukemia virus type I (HTLV‐I). Our experiments with rabbits have shown that passive immunization is capable of blocking ceil‐to‐cell infection of HTLV‐I by blood transfusion or breast feeding. In this study, sera were collected serially from 3 infants born to seropositive mothers and were tested for the presence of neutralizing antibody to vesicular stomatitis virus (HTLV‐I) pseudotype as well as antibodies to viral structural proteins. There was a good correlation between neutralizing and viral antibody titers, both of which were detectable until 3–6 months after birth. Whether maternally transmitted neutralizing antibody is protective against perinatal infection of HTLV‐I remains to be studied.