Open AccessInfiltrating Lymphocytes and Accessory Cells in Nasopharyngeal Carcinoma 1
Author(s) -
Zong Yongsheng,
Zhang Changqing,
Zhang Feng,
Kuan Jianbo,
Chen Moye,
Feng Kaitao,
Yu Zhaofang
Publication year - 1993
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1993.tb02064.x
Subject(s) - nasopharyngeal carcinoma , immunostaining , lymph node , medicine , immune system , radiation therapy , pathology , metastasis , cancer , lymph , carcinoma , immunology , cancer research , immunohistochemistry
The infiltrating lymphocytes (LCs) and accessory cells (ACs) including dendritic cells (DCs) and monocytes/macrophages in nasopharyngeal biopsies taken from 4 groups of nasopharyngeal carcinoma (NPC) patients were observed by using an immunostaining technique and the correlation of the results to the clinical manifestations and follow‐up data was examined. The findings were as follows. (1) NPCs without lymph node metastasis always had marked infiltrating LCs and DCs as compared with those with lymph node(s) metastasis. (2) Advanced NPCs with lymph node(s) involvement (T1–4N1–3M0) and a rapid development of distant metastasis followed by death within 1 year after radiotherapy always showed fewer infiltrating LCs and DCs as compared with those with lymph node(s) metastasis (T1–4N1–3M0) and having longer than 5‐year survival after radiotherapy. The amount of both LCs and ACs, especially DCs, infiltrating in NPC tissues appears to be an indicator of the activity of host immune defence mechanisms against cancer and influences the progression of the neoplasm as well as the prognosis.