Open AccessChromosomal Mapping of Genetic Locus Associated with Thymus‐size Enlargement in BUF/Mna Rats
Author(s) -
Murakumo Yoshiki,
Takahashi Masahide,
Arakawa Atsushi,
Saito Mitsuhiro,
Amo Hiroyuki,
Katoh Hideki,
Matsuyama Mutsushi
Publication year - 1993
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1993.tb02054.x
Subject(s) - locus (genetics) , biology , genetics , gene mapping , medicine , gene , chromosome
The thymoma‐prone rat of the BUF/Mna strain is a useful model for human thymoma. In this strain thymoma development is regulated by a single autosomal susceptible gene, Tsr‐1. At pre‐thymoma age, BUF/Mna rats have extremely large thyrauses, when compared to those of other strains of rats. Genetic studies in crosses between BUF/Mna rats with large thymuses and WKY/NCrj rats with small thymuses suggested the presence of a major autosomal gene, Ten‐1 , which contributes to thymus enlargement in a backcross population. Linkage studies between Ten‐1 and microsatellite markers in backcross rats of (WKY/NCrj×BUF/Mna)Fl×BUF/Mna have led to the localization of Ten‐1 in chromosome 1. This result may provide an approach to clone Tsr‐1 , which could be allelic to Ten‐1.