Open AccessPotentiation of Metastatic Capacity by Transforming Growth Factor‐β1 Gene Transfection
Author(s) -
Ueki Noboru,
Ohkawa Toshihisa,
Yokoyama Yuji,
Maeda Juichiro,
Kawai Yutaka,
Ikeda Tatsuhiko,
Amuro Yoshiki,
Hada Toshikazu,
Higashino Kazuya
Publication year - 1993
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1993.tb02017.x
Subject(s) - transfection , chinese hamster ovary cell , transforming growth factor , angiogenesis , biology , hamster , cancer research , growth factor , cell culture , endocrinology , genetics , receptor
This study was designed to assess whether the excessive secretion of transforming growth factor‐β1 (TGF‐β1) by Chinese hamster ovary (CHO) cells transfected with TGF‐β1 gene may be linked to the development of a metastatic phenotype. We observed large numbers of metastatic colonies in the lungs of nude mice inoculated with the transfected CHO cells. The tumors derived from these transfected cells demonstrated marked angiogenesis. We postulate that the overproduction of TGF‐β1 by these tumors may participate in the metastatic progression following establishment of angiogenesis at the primary tumor site.