Open AccessImmunohistochemical Analysis of Cathepsin B Expression in Human Lung Adenocarcinoma: The Role in Cancer Progression
Author(s) -
Ozeki Yuichi,
Takishima Kunio,
Takagi Keigo,
Aida Shinsuke,
Tamai Seiichi,
Mamiya Gunji,
Ogata Toshiro
Publication year - 1993
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1993.tb00187.x
Subject(s) - immunohistochemistry , adenocarcinoma , cathepsin b , pathology , metastasis , cathepsin d , biology , lung cancer , cancer research , cancer , medicine , enzyme , biochemistry
Production of cathepsin B by tumor cells has been linked to metastatic potential in several experimental models. Sections of 95 primary lung adcnocarcinomas were examined for expression of cathepsin B using a standard avidin‐biotin immunohistochemical technique. Staining for cathepsin B was observed in 22.1% of all cases and 28.0% of those of the Clara cell type. In Clara cell adenocarcinomas, cathepsin B expression correlated with positive lymph node status, presence of distant metastases, and poor prognosis ( P <0.05). However, no correlation with clinical outcome was observed in other cell types. Our data suggest that cathepsin B may be involved in invasion and metastasis in Clara cell lung adenocarcinoma.