Open AccessVertical Transmission of HTLV‐1 in HTLV‐1 Carrier Rat
Author(s) -
Ami Yoshihiro,
Kushida Shigeki,
Matsumura Masayuki,
Yoshida Yuki,
Kameyama Tsuneo,
Sugiyama Yoshihiro,
Yagami Kenichi,
Uchida Masako,
Uchida Kazuhiko,
Koiso Kenkichi,
Miwa Masanao
Publication year - 1992
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1992.tb02751.x
Subject(s) - provirus , peripheral blood mononuclear cell , offspring , virology , transmission (telecommunications) , polymerase chain reaction , biology , peripheral blood , microbiology and biotechnology , medicine , immunology , andrology , in vitro , genetics , pregnancy , gene , genome , electrical engineering , engineering
A female F344 rat was injected with 2.4 × 10 6 MT‐2 cells intravenously at 3 and 4 weeks old, and was mated with a non‐infected male rat at the 17th week after injection, when the dam rat contained HTLV‐1 provirus in the peripheral blood mononuclear cells as determined by polymerase chain reaction. HTLV‐1 provirus was detected in at least 2 out of 9 offspring. This system should be useful for studies on the routes and prevention of vertical transmission and on elimination of once‐transmitted HTLV‐1.