Open AccessOptimal Electric Conditions in Electrical Impulse Chemotherapy
Author(s) -
Okino Motonori,
Tomie Hiroshi,
Kanesada Hirohiko,
Marumoto Masaru,
Esato Kensuke,
Suzuki Hiroshi
Publication year - 1992
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1992.tb02727.x
Subject(s) - impulse (physics) , voltage , bleomycin , chemotherapy , in vivo , pulse duration , intramuscular injection , materials science , chemistry , medicine , electrical engineering , biology , physics , laser , microbiology and biotechnology , optics , quantum mechanics , engineering
The relationship was examined between the tumoricidal effect and the electrical variables of in vivo electrical impulse chemotherapy. Donryu rats subcutaneously inoculated with AH‐109AY hepatocellular carcinomas were given a single high‐voltage electrical impulse of varying voltage and duration, 30 min after an intramuscular injection of 4 mg/kg bleomycin. As the voltage ( V ) was increased from 0 to 5 kV, the tumoricidal effect ( E ) increased in proportion to the square of the voltage. As the pulse duration ( D ) was increased from 2.5 to 5.8 ms, the tumoricidal effect increased in direct proportion to it. Combining these results yielded the formula, E=γV 2 D, which indicates that tumoricidal efficacy was proportional to the applied electrical energy. When the electrical energy was kept constant while varying the voltage and duration of pulse, the anticancer effect was the same, confirming this relationship for lower energy levels.