Open AccessAnti‐promoting Effect of Nordihydroguaiaretic Acid on N‐Butyl‐N‐(4‐hydroxybutyl)nitrosamine and Sodium Saccharin‐induced Rat Urinary Bladder Carcinogenesis
Author(s) -
Yu Akinori,
Hashimura Takayuki,
Nishio Yasunori,
Kanamaru Hiroshi,
Fukuzawa Shigeki,
Yoshida Osamu
Publication year - 1992
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1992.tb02005.x
Subject(s) - nordihydroguaiaretic acid , nitrosamine , chemistry , carcinogen , endocrinology , medicine , hyperplasia , papilloma , oral administration , arachidonic acid , biochemistry , pathology , enzyme
The effects of oral administration of nordihydroguaiaretic acid (NDGA), an antioxidant and inhibitor of arachidonic acid metabolism, on rat bladder carcinogenesis were examined. Six‐week‐old male Fischer 344 rats were given drinking watar containing 0.05% N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine for 4 weeks. Following this 4‐week period, diet containing 5% sodium saccharin (SS) with or without 0.1% NDGA supplement was given to the rats for 36 weeks. The incidences of papillary or nodular (PN) hyperplasia and of papilloma in the group treated with SS plus NDGA were significantly lower than those in the group treated with SS alone. The number of PN hyperplasic foci per 10 cm of basement membrane in rats treated with SS plus NDGA was also lower than that in the group treated with SS alone. These results suggest that NDGA has an anti‐tumor‐promoting effect on rat bladder carcinogenesis.