Open AccessInduction of Adenocarcinomas in the Glandular Stomach of BALB/c Mice Treated with N‐Methyl‐N‐nitrosourea
Author(s) -
Tatematsu Masae,
Ogawa Kumiko,
Hoshiya Toru,
Shichino Yutaka,
Kato Toshio,
Imaida Katsumi,
Ito Nobuyuki
Publication year - 1992
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1992.tb01999.x
Subject(s) - stomach , adenocarcinoma , signet ring cell , pathology , lymph , nitrosourea , biology , incidence (geometry) , medicine , gastroenterology , cancer , chemotherapy , physics , optics
Male 6‐week‐old BALB/c strain animals (groups 1 and 2) received 10 weekly intragastric intubations of 0.5 mg/mouse of N‐methyl‐N‐nitrosourea. At week 11 the forestomachs were resected in group 1 but not group 2. Although many animals in group 2 died due to development of squamous cell carcinomas in the forestomach, development of cancers in the glandular stomach was quite similar in both groups. Well‐differentiated adenocarcinomas in groups 1 and 2 were found at low incidence at week 20, rising to 100% at week 40, with two lesions metastasizing to the lymph nodes. Four poorly differentiated adenocarcinomas and 5 signet ring cell carcinomas were also found in 27 glandular stomach tumor‐bearing animals.