Open AccessCD7 Expression in Malignant Pleural Mesothelioma
Author(s) -
Hibi Shigeyoshi,
Kataoka Yoshiko,
Fujita Naohisa,
Okabe Hidetoshi,
Yoshikawa Kazuhiro,
Seto Masao,
Ueda Ryuzo,
Imashuku Shinsaku
Publication year - 1992
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1992.tb01965.x
Subject(s) - mesothelioma , monoclonal antibody , immunostaining , pathology , pleural disease , haematopoiesis , jurkat cells , immunohistochemistry , biology , cancer research , antigen , medicine , stem cell , antibody , respiratory disease , immunology , t cell , immune system , lung , genetics
CD7 antigen was found to be expressed on malignant mesothelioma arising from the right pleura in a 15‐year‐old girl not only by immunostaining using monoclonal antibodies, but also by Northern blot analysis. The level of expression in this tumor was comparable to those in T‐cell lines, Jurkat and CCRF‐CEM. Cytogenetic analysis of the tumor showed hypodiploidy (n = 43). CD7 has been regarded as one of the hematopoietic cell markers selectively expressed on the majority of T cells and multipotential stem cells. To our knowledge, this is the first report of a non‐hematopoietic tumor expressing CD7.