Open AccessMetabolism of Tegafur in Rat Liver Observed by in vivo 19 F Magnetic Resonance Spectroscopy and Chromatography
Author(s) -
Harada Masafumi,
Nishitani Hiromu,
Koga Keiko,
Miura Iwao,
Umeno Yukihiko
Publication year - 1992
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1992.tb00119.x
Subject(s) - tegafur , in vivo , uracil , chemistry , metabolism , nuclear magnetic resonance spectroscopy , catabolism , floxuridine , chromatography , biochemistry , medicine , fluorouracil , chemotherapy , biology , stereochemistry , dna , microbiology and biotechnology
Metabolism of tegafur in the rat liver was observed by in‐vivo 19 F magnetic resonance spectroscopy (MRS). After MRS observation, tegafur and q‐fluorouracil (S‐FU) in the liver were determined by a shromatographic method for comparison with the results of 19 F‐MRS. Rats were divided into 3 groups: 1) CCl4‐induced liver injury group, 2) uracil combined group, 3) control group. Catabolism to fluoro‐β‐alanine was suppressed in both the liver injury group and the uracil combined group. Low peaks of 5‐FU and fluoronucleotides could be found only in the uracil combined group. The result of 19 F MRS observation of each group was in agreement with the result of determination of tegafur and 5‐FU by chromatography. This showed that substances which could be observed by 19 F‐MRS were in proportion to all intracelluar fluoro‐containing substances. 19 F‐MRS can provide direct information on the metabolism of fluoropyimidines non‐invasivey and it might be a useful aid in choosing suitable shemotherapy for patients.