Open AccessEvidence of Sex Difference in DNA Synthesis in Hepatocellular Carcinoma
Author(s) -
Tarao Kazuo,
Shimizu Akio,
Harada Masaoki,
Ono Tetsuo,
Kuni Yukifusa,
Ohkawa Shinichi,
Ito Yoshihiko,
Tamai Setsuo,
Limori Kazuto,
Sugimasa Yukio,
Takemiya Shoji,
Okamoto Takashi,
Inoue Tohru,
Kanisawa Masayoshi
Publication year - 1991
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1991.tb01922.x
Subject(s) - hepatocellular carcinoma , carcinoma , dna , oncology , biology , medicine , cancer research , pathology , genetics
To clarify sex differences in DNA synthesis in hepatocellular carcinoma (HCC), bromodeoxyuridine labeling indices (BrdU LI) of HCC cells included in tumor biopsy specimens from 12 consecutive male patients and from 5 consecutive female patients all with liver cirrhosis and HCC were examined using an in vitro labeling technique. The mean BrdU LI ± SE of HCC from male patients (7.7 ±0.8%) was significantly (P<0.05) higher than that from female patients (4.4± 1.0%). While 7 of the 12 male HCC patients belonged to the high DNA synthesis group (BrdU LI ≥7.0%), none of the 5 female HCC patients showed high DNA synthesis (P<0.05). We conclude that DNA synthesis in HCC was higher in males than in females.