Open AccessInduction of Aberrant Crypt Foci in the Large Intestine of F344 Rats by Oral Administration of 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
Author(s) -
Takahashi Satoru,
Ogawa Kumiko,
Ohshima Hiroshi,
Esumi Hiroyasu,
Ito Nobuyuki,
Sugimura Takashi
Publication year - 1991
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1991.tb01819.x
Subject(s) - aberrant crypt foci , carcinogen , large intestine , crypt , chemistry , medicine , oral administration , 1,2 dimethylhydrazine , dimethylhydrazine , small intestine , pathology , endocrinology , gastroenterology , biochemistry , colorectal cancer , colonic disease , cancer
Carcinogenicity of 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐ b ]pyridine (PhIP) to rat colon was investigated using the appearance of colonic aberrant crypt (AC), a preneoplastic lesion, as a marker. The number of AC foci per colon at experimental week 4 was 1.3 ± 0.8; almost half the level of AC foci induced by 2‐amino‐6‐methyIdipyrido[l,2‐ a :3′,2′‐ d ]imidazole (Glu‐P‐1), which is a known colon carcinogen. No ACs were observed in rats of the control group. A repeat experiment showed that induction of AC foci by PhIP administration was reproducible and a significant increase in the number of AC foci, 3.0 ±0.0, was observed after 12 weeks of PhIP administration. The majority of ACs induced by PhIP were localized in the distal part of the colon. The distribution was similar to those induced by Glu‐P‐1 and 1,2‐dimethylhydrazine. Those data suggested that PhIP is possibly carcinogenic to rat colon.