Open AccessA Possible Error in the Interpretation of Gastric Carcinoma
Author(s) -
Rubio Carlos,
Hirota Teruyuki,
Itabashi Masayuki,
Hirohashi Setsuo,
Yo Yo
Publication year - 1991
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1991.tb01805.x
Subject(s) - cytoplasm , mucin , adenocarcinoma , signet ring cell , eosinophilic , pathology , foveolar cell , signet ring cell carcinoma , homogeneous , biology , gastric mucosa , stomach , cancer , medicine , microbiology and biotechnology , biochemistry , physics , genetics , thermodynamics
Isolated clusters of pyloric cells having homogeneous, eosinophilic (i.e., “glassy”) cytoplasm were present in 6 (18.2%) of 33 consecutive gastrectomy specimens. Clusters with “glassy” cells displayed either a glandular arrangement or appeared as cohesive clusters. Cohesive clusters could be misinterpreted as signet‐ring cell adenocarcinoma. However, remnants of the apical mucous secretion from the “ordinary” pyloric cells, the nuclei usually near the free border of the cells, as well as the negative reaction in the “glassy” cytoplasm for neutral and acid mucins, helped to differentiate them from signet‐ring adenocarcinoma cells.