Open AccessEffects of Hormones on Tumor Growth and Immunoreactive Insulin–like Growth Factor–1 of Estrogen Receptor–positive Human Breast Cancer (MCF‐7) Transplanted in Nude Mice
Author(s) -
Noguchi Masakuni,
Koyasaki Naohiro,
Miyazaki Itsuo,
Yuji Yuji
Publication year - 1991
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1991.tb01780.x
Subject(s) - endocrinology , medicine , tamoxifen , estrogen , mcf 7 , estrogen receptor , antiestrogen , insulin like growth factor , growth factor , cancer , breast cancer , hormone , in vivo , mammary gland , receptor , thymidine , biology , human breast , in vitro , biochemistry , microbiology and biotechnology
The effects of estrogens and tamoxifen were analyzed on estrogen receptor–positive human breast cancer (MCF–7) transplanted into athymic nude mice. It was found that (1) the tumor growth and the proportion of 3 H–thymidine –labeled cells were significantly increased in the 17β– estradiol dipropionate (E 2 ) group, but significantly decreased In the tamoxifen (TAM) group with respect to the control group, and (2) the tumor content of insulin–like growth factor–1 (IGF–1) and the rate of IGF–1–positive cells were significantly lower in the E 2 group, but significantly higher in the TAM group than in the control group. It was concluded that the tumor content of IGF–1 and the proportion of IGF–I–positive cells were inversely correlated to the tumor growth and the 3 H–thymidine labeling index in vivo ,