Induction of Signet Ring Cell Carcinomas in X‐Irradiated Hypocatalasemic Mice (C3H/Ob8) | Zendy

Watanabe Hiromitsu | Zendy; Ogundigie Peter Osa | Zendy; Takahashi Tadateru | Zendy; Ishimoto Tatsuro | Zendy; Ito Akihiro | Zendy

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Induction of Signet Ring Cell Carcinomas in X‐Irradiated Hypocatalasemic Mice (C3H/Ob8)

Author(s) -

Watanabe Hiromitsu,

Ogundigie Peter Osa,

Takahashi Tadateru,

Ishimoto Tatsuro,

Ito Akihiro

Publication year - 1991

Publication title -

japanese journal of cancer research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.035

H-Index - 141

eISSN - 1349-7006

pISSN - 0910-5050

DOI - 10.1111/j.1349-7006.1991.tb01774.x

Subject(s) - stomach , signet ring cell , pathology , irradiation , biology , medicine , adenocarcinoma , cancer , physics , nuclear physics

The stomach region of hypocatalasemic mice of both sexes was X‐irradiated once with a dose of 20 Gy. Thirteen months after the irradiation, 3 out of 13 (20%) males and 2 out of 9 (15%) females were observed to have developed signet ring cell carcinomas in the glandular stomach. This finding was statistically significant (P < 0.01 in males and P < 0.05 in females) compared to a total absence of similar tumors in the non‐irradiated controls. Local invasion of malignant tumors into muscle and subserosal layers was observed, but no metastatic tumors were found in distant organs.

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