Open AccessThe Role of Bone Fracture at the Site of Carcinogen Exposure on Nickel Carcinogenesis in the Soft Tissue
Author(s) -
Ohmori Takaaki,
Uraga Naomi,
Komi Kiyoshi,
Tabei Ryo,
Shibata Taiho
Publication year - 1990
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1990.tb02686.x
Subject(s) - soft tissue , carcinogenesis , carcinogen , pathology , metastasis , medicine , anatomy , chemistry , cancer , biochemistry
The influence upon nickel subsulfide (α‐Ni 3 S 2 ; Ni‐SS)‐induced carcinogenesis in the soft tissue of bone fracture at the site of Ni‐SS exposure was studied using female Fischer rats. During the one year of the experiment, the group subjected to bone fracture exhibited the shortest tumor induction time and survival time, and a significantly higher metastatic rate. The present study may suggest a model for the metastasis of human soft tissue tumors.