Open AccessEffects of Sodium Nitrite and Catechol or 3‐Methoxycatechol in Combination on Rat Stomach Epithelium
Author(s) -
Hirose Masao,
Fukushima Shoji,
Hasegawa Ryohei,
Kato Toshio,
Tanaka Hikaru,
Ito Nobuyuki
Publication year - 1990
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1990.tb02657.x
Subject(s) - catechol , sodium nitrite , nitrite , hyperplasia , epithelium , stomach , chemistry , medicine , endocrinology , biochemistry , pathology , food science , organic chemistry , nitrate
The effects of sodium nitrite (NaNO 2 ) and catechol or 3‐methoxycatechol in combination were examined in male F344 rats. Animals were treated with 0.3% NaNO 2 in the drinking water and 0.8% catechol or 2% 3‐methoxycatechol in powdered diet for 24 weeks. While catechol or 3‐methoxycatechol alone induced low incidences of mild or moderate hyperplasia, simultaneous administration of NaNO 2 markedly enhanced the degree of hyperplasia and papilloma formation. In contrast, induction of submucosal hyperplasia and adenomas in the glandular epithelium was reduced. Thus, the results indicate that NaNO 2 can modulate the metabolism of antioxidants, so that, possibly via production of new active moieties, targeting of forestomach epithelium is enhanced.