Open AccessLoss of Heterozygosity on Chromosomes 1 and 11 in Sporadic Pheochromocytomas
Author(s) -
Yokogoshi Yutaka,
Yoshimoto Katsuhiko,
Saito Shiro
Publication year - 1990
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1990.tb02620.x
Subject(s) - loss of heterozygosity , locus (genetics) , biology , genetics , multiple endocrine neoplasia , chromosome , chromosome 3 , gene , cytogenetics , cancer research , allele , microbiology and biotechnology
Molecular genetic analysis was performed with 20 oncogene probes and 32 polymorphic DNA probes on tumor DNA samples from seven pheochromocytomas; namely, one multiple endocrine neoplasia type 2B, and two familial and four sporadic pheochromocytomas. No amplification or rearrangement of the oncogenes was detected in any of the tumors. However, loss of heterozygosity on chromosome 1p, 11p or 11q was detected in these cases. In addition, a locus related to ETS1 was deleted in two of the sporadic tumors. These results suggest that pheochromocytomas may be genetically heterogeneous, and that inactivation of unknown genes on chromosome 1p, 11p or 11q may contribute to their development.