Open AccessCorrespondence in Cancer History between Husbands and Wives
Author(s) -
Kato Ikuko,
Tominaga Suketami,
Suzuki Tsuguyoshi
Publication year - 1990
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1990.tb02613.x
Subject(s) - medicine , cancer , bladder cancer , colorectal cancer , family history , confidence interval , lung cancer , family aggregation , stomach cancer , esophageal cancer , population , cohort , disease , gastroenterology , cohort study , environmental health
To study the effect of the environments shared by spouses on the development of cancer and some chronic diseases, we analyzed the correspondence of disease history in 21,592 fathers and mothers using the baseline data of a population‐based cohort study. The observed number of cases (O) whose parents had the same disease history was statistically significantly greater than the expected (E); the O/E ratio was 1.53 (95% confidence interval (CI): 1.43–1.63) for all malignant neoplasms, 5.22 (95% CI: 2.81–9.70) for esophageal cancer, 1.63 (95% CI: 1.37–1,93) for stomach cancer, 3.01 (95% CI: 1.89–4.79) for colorectal cancer, 3.90 (95% CI: 2.75–5.53) for liver cancer, 3.14 (95% CI: 1.95–5.08) for lung cancer, 6.73 (95% CI: 2.53–17.87) for bladder cancer, 1.66 (95% CI: 1.54–1.78) for apoplexy and 1.67 (95% CI: 1.51–1.86) for heart disease. The results of the present study suggest that the environmental factors shared by family members for a long time may contribute to familial aggregation of cancer and some chronic diseases.