Open AccessChanges in Number of α‐Adrenergic Receptor Subtypes in Hepatocytes from Rats Fed 3′‐Methyl‐4‐dimethylaminoazobenzene
Author(s) -
Miyamoto Kenichi,
Sanae Fujiko,
Kohei Keiko,
Nomura Masaaki,
Koshiura Ryozo
Publication year - 1990
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1990.tb02607.x
Subject(s) - receptor , endocrinology , medicine , adrenergic receptor , carcinogen , prazosin , adrenergic , chemistry , clonidine , biology , biochemistry , antagonist
Changes in numbers of α 1 ‐ and α 2 ‐adrenergic receptors in the plasma membranes of hepatocytes from female Donryu rats given feed containing 0.06% of the carcinogen 3′‐methyl‐4‐dimethylamino‐azobenzene (3′‐MeDAB), were examined. α 1 ‐Adrenergic receptors, measured in terms of [ 3 H]‐prazosin binding, decreased to half of the control 2 weeks after the start of this diet, then gradually decreased for the next 22 weeks. α 2 ‐Adrenergic receptors, measured in terms of [ 3 H]clonidine binding, transiently increased 3‐fold over the control at 2 weeks. These changes in the early period of the 3′‐MeDAB diet intake may be related to hepatocarcinogenesis.