Open AccessPrevalence of Antibody against Non‐A, non‐B Hepatitis Virus in Japanese Patients with Hepatocellular Carcinoma
Author(s) -
Ohkoshi Showgo,
Kojima Hideo,
Tawaraya Hironobu,
Miyajima Tohru,
Kamimura Tomoteru,
Asakura Hitoshi,
Satoh Akira,
Hirose Shinichi,
Hijikata Makoto,
Kato Nobuyuki,
Shimotohno Kunitada
Publication year - 1990
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1990.tb02605.x
Subject(s) - hepatocellular carcinoma , hbsag , medicine , antibody , hepatitis b virus , hepatitis c virus , carcinoma , blood transfusion , hepatitis , gastroenterology , hepatitis b , virus , virology , immunology
Antibodies against a possible causative agent of non‐A, non‐B hepatitis, hepatitis C virus (HCV), in Japanese patients with hepatocellular carcinoma were analyzed using the enzyme‐linked immunosorbent assay (ELISA) system from Ortho Diagnostic Systems, Japan. Fifty of 58 cases of hepatitis B virus surface antigen (HBsAg)‐negative hepatocellular carcinoma were positive for the antibody (86%) and 8 of 42 cases of HBsAg‐positive hepatocellular carcinoma were positive (19%). Among patients with HBsAg‐negative hepatocellular carcinoma, the prevalence of the antibody was greater among those who had received a blood transfusion (97%) than among those with no history of transfusion (70%). Only 3 of 54 patients with cancers other than hepatocellular carcinoma were found to be antibody‐positive (5.6%) and all three patients had a history of blood transfusion. These results show a close relationship between the presence of anti‐HCV antibody and HBsAg‐negative hepatocellular carcinoma in Japan.