Open AccessUrothelial Damage and Tumor Initiation by Urinary Metabolites of Sodium o ‐Phenylphenate in the Urinary Bladder of Female Rats
Author(s) -
Hasegawa Ryohei,
Furukawa Fumio,
Toyoda Kazuhiro,
Sato Hidetaka,
Takahashi Michihito,
Hayashi Yuzo
Publication year - 1990
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1990.tb02595.x
Subject(s) - metabolite , urinary system , urinary bladder , hyperplasia , urothelium , urology , chemistry , epithelium , saline , sodium , medicine , endocrinology , pathology , organic chemistry
Intravesical instillation of 2‐phenyl‐1,4‐benzoquinone (PBQ), a metabolite of sodium o ‐phenylphenate (Na‐OPP), at a concentration of 0.1% in saline caused acute epithelial injury, prolonged inflammation and epithelial hyperplasia in female F344 rats. Ten such instillations of PBQ within 5 weeks resulted in the development of preneoplastic lesions of the urinary bladder epithelium when followed by 5% sodium saccharin feeding for 31 weeks. Since neither urothelial damage nor tumor‐initiating activity was observed with either Na‐OPP itself or another metabolite, phenylhydroquinone, PBQ may play an essential role in Na‐OPP urinary bladder carcinogenesis.