Open AccessAntimetastatic and Growth‐inhibitory Effects of N ‐Acetylchitohexaose in Mice Bearing Lewis Lung Carcinoma
Author(s) -
Tsukada Keiko,
Matsumoto Tatsuji,
Aizawa Kazuhiro,
Tokoro Akio,
Naruse Ryusuke,
Suzuki Shigeo,
Suzuki Masuko
Publication year - 1990
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1990.tb02559.x
Subject(s) - lewis lung carcinoma , mastocytoma , ratón , carcinoma , lung , metastasis , spleen , inhibitory postsynaptic potential , cancer research , growth inhibition , immunology , pathology , medicine , biology , endocrinology , apoptosis , tumor cells , cancer , biochemistry
N ‐Acetylchitohexaose, a water‐soluble oligosaccharide was found to display a significant anti‐metastatic effect against Lewis lung carcinoma (LLC) transplanted into C57BL/6 mice, giving rise to a 40–50% inhibition ratio of pulmonary metastasis when administered intravenously (1 mg/kg) on day 6 after the tumor implantation (5 × 10 5 cells/mouse). It was also revealed that this hexaose had a significant growth‐inhibitory effect against the local tumor of the same carcinoma (a 20–30% inhibition ratio), showing an enhancing effect on concomitant immunity in local tumor‐resected mice. This oligosaccharide was also shown to enhance the tumoricidal effect of splenic T lymphocytes against LLC and P‐815 mastocytoma cells and to increase the natural killer activity of splenic T lymphocytes, assayed with YAC‐1 cells as the target.