Open AccessCyclophosphamide‐dependent Lymph Node Modification in Lymph Node Metastasis of MM48 Tumor Cells in Syngeneic Mice
Author(s) -
Yoshida Kikuyoshi,
Tachibana Takehiko
Publication year - 1990
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1990.tb02558.x
Subject(s) - lymph , lymph node , cyclophosphamide , medicine , metastasis , lymph node stromal cell , primary tumor , immune system , cancer research , pathology , immunology , chemotherapy , cancer
We investigated the role of immunosuppressive activity induced in the regional lymph nodes (RLN, popliteal lymph nodes) in the establishment of lymph node metastasis by cyclophosphamide (CY) administration. The CY treatment led to the elimination of suppressive activity with the appearance of positive immune responses, and the inhibition of lymph node metastasis of MM48 tumor cells. In CY‐treated mice, the removal of RLN together with the primary tumor lowered the survival rate compared with the mice in which the RLN remained intact. During 4 days after primary tumor resection, the proliferation of tumor cells in the RLN was significantly decreased in CY‐treated mice. These results suggested that the induction of suppressive activity in the lymph node is closely associated with the establishment of lymph node metastasis.