Open AccessModulation of c‐ myc Expression by Transforming Growth Factor β1 in Human Hepatoma Cell Lines
Author(s) -
Ito Nobuyuki,
Kawata Sumio,
Tamura Shinji,
Takaishi Kenji,
Saitoh Ryuzo,
Tarui Seiichiro
Publication year - 1990
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1990.tb02552.x
Subject(s) - cell culture , transforming growth factor , modulation (music) , biology , cell growth , cancer research , microbiology and biotechnology , genetics , physics , acoustics
The effects of transforming growth factor β1 (TGF‐β1) on cell proliferation of human hepatoma cell lines, PLC/PRF/5 and Mahlavu, were investigated under serum‐free conditions. DNA synthesis was strongly inhibited in the PLC/PRF/5 cells by addition of TGF‐β1 (0.5 to 4.0 ng/ml), but remained unchanged in the Mahlavu cells. Also the expression of c‐ myc mRNA was suppressed by the addition of TGF‐β1 in the PLC/PRF/5 cells but not in the Mahlavu cells. These results indicate that TGF‐β1 might regulate cell growth, in part, by modulating c‐ myc expression, although there is no direct proof that c‐ myc expression is really relevant to DNA synthesis mediated by TGF‐β1.