Open AccessStomach Carcinogenicity of Caffeic Acid, Sesamol and Catechol in Rats and Mice
Author(s) -
Hirose Masao,
Fukushima Shoji,
Shirai Tomoyuki,
Hasegawa Ryohei,
Kato Toshio,
Tanaka Hikaru,
Asakawa Emiko,
Ito Nobuyuki
Publication year - 1990
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1990.tb02550.x
Subject(s) - caffeic acid , sesamol , stomach , carcinogen , catechol , endocrinology , medicine , chemistry , antioxidant , biochemistry
The carcinogenic potential of caffeic acid, sesamol and catechol was examined in male and female F344 rats and B6C3F 1 mice, groups of 30 animals being treated with diets containing 2% caffeic acid, 2% sesamol or 0.8% catechol for 104 weeks (rats) or 96 weeks (mice). Histological examination revealed that caffeic acid induced forestomach squamous cell carcinoma in 57% ( P <0.001 vs. controls) and 50% ( P <0.001) of male and female rats, respectively, whereas sesamol was associated with squamous cell carcinoma at incidences of 31% ( P <0.001) in male rats, and 38% ( P <0.001) and 17% ( P <0.05) in male and female mice, respectively. Catechol induced glandular stomach adenocarcinomas in 54% ( P <0.001) and 43% ( P <0.001) of male and female rats, respectively. The results thus clearly demonstrated that all three antioxidants are carcinogenic in rodent stomach epithelia.