Open AccessEvaluation of Mizoribine as an Immunosuppressant in Subrenal Capsule Assay Using Immunocompetent Mice
Author(s) -
Chen DongYi,
Kikuchi Hiroaki,
Asamura Mitsuo,
Gamoh Makio,
Wakui Akira
Publication year - 1990
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1990.tb02546.x
Subject(s) - mizoribine , capsule , chemotherapy , medicine , chemistry , pharmacology , biology , botany
We studied the application of mizoribine (MZR) to normal immunocompetent mice in subrenal capsule assay (SRCA) by means of tumor growth curve determination, histological analysis and autoradiography. At 400 mg/kg, MZR prolonged the actual tumor growth and moderately reduced the host reaction. Doses below 200 mg/kg did not effectively suppress the host reaction. The maximal weight loss of mice in the 400 mg/kg group reached 29%, but did not exceed 10% within 8 days. Hence, we applied 400 mg/kg of MZR to SRCA for up to eight days for cancer chemotherapy testing. This dose of MZR did not affect the labeling index of tumor cells compared with the control.