Open AccessFrequent Loss of Heterozygosity on Chromosomes 16 and 4 in Human Hepatocellular Carcinoma
Author(s) -
Zhang Wandong,
Hirohashi Setsuo,
Tsuda Hitoshi,
Shimosato Yukio,
Yokota Jun,
Terada Masaaki,
Sugimura Takashi
Publication year - 1990
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1990.tb02534.x
Subject(s) - loss of heterozygosity , locus (genetics) , biology , hepatocellular carcinoma , allele , genetics , restriction fragment length polymorphism , chromosome , microbiology and biotechnology , genotype , gene
By restriction fragment length polymorphism analysis, we examined loss of heterozygosity at 34 loci on 23 chromosomes in 35 surgically resected human hepatocellular carcinomas. Allele losses at the HP locus on chromosome 16q22 and at the MT2P1 locus on chromosome 4p11‐q21 were detected in 57% (8/14) and 50% (8/16) of cases, respectively. Loss of heterozygosity on chromosomes 16q and 4 occurred simultaneously in 4 of 7 informative cases for both loci, and seemed to be important in the development of human hepatocellular carcinoma irrespective of the presence of hepatitis B virus infection. In contrast, the incidence of allele loss was low at the other loci, e.g., chromosome 1p, 3p, 11p, 13q or 17p, where one allele is frequently lost in other cancers.