Open AccessA Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection
Author(s) -
Kato Nobuyuki,
Hijikata Makoto,
Ootsuyama Yuko,
Nakagawa Masanori,
Ohkoshi Showgo,
Shimotohno Kunitada
Publication year - 1990
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1990.tb02518.x
Subject(s) - virology , hepatitis c virus , virus , hepatocellular carcinoma , biology , genome , viral structural protein , transcription (linguistics) , antibody , viral disease , gene , immunology , viral replication , cancer research , genetics , viral entry , linguistics , philosophy
A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non‐structural protein, C100, of hepatitis C virus, but not by sera from healthy persons. Thus, this structural protein should be useful for detection of infection with this virus.