
Transition of Antibody to Hepatitis C Virus from Chronic Hepatitis to Hepatocellular Carcinoma
Author(s) -
Kiyosawa Kendo,
Tanaka Eiji,
Sodeyama Takeshi,
Furuta Kiyoshi,
Usuda Seiichi,
Yousuf Muhammad,
Furuta Seiichi
Publication year - 1990
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1990.tb02517.x
Subject(s) - hepatocellular carcinoma , medicine , cirrhosis , hepatitis c virus , hepatitis , hepatitis c , liver cancer , virus , gastroenterology , viral hepatitis , cancer , virology
Fifty‐eight patients with chronic hepatitis C were followed for more than 7 years. Of them, 10 patients were found to develop hepatocellular carcinoma, 14 to develop liver cirrhosis, 30 to sustain chronic hepatitis, and 4 to show subsidence of hepatitis. Antibody to hepatitis C virus (anti‐HCV) disappeared from the 4 patients whose hepatitis subsided, but it persisted in the remaining 54 patients. The mean titer of anti‐HCV was almost the same at the stages of chronic hepatitis and of cancer in the 10 patients who developed hepatocellular carcinoma. These results indicate that chronic infection of hepatitis C virus may lead to hepatocellular carcinoma.