Open AccessProliferative Cell Index in Endometrial Adenocarcinoma of Different Nuclear Grades
Author(s) -
Mushika Masafumi,
Shibata Kanemitsu,
Miwa Tadashi,
Suzuoki Yozo,
Kaneda Tsuguhiro
Publication year - 1989
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1989.tb02296.x
Subject(s) - conventional pci , adenocarcinoma , endometrial cancer , stage (stratigraphy) , medicine , nuclear medicine , pathology , biology , cancer , paleontology , myocardial infarction
Proliferative cell indices (PCI) in 20 cases of endometrial adenocarcinoma were obtained by staining DNA polymerase α. The PCI ranged from 11.1 to 42.1, averaging 24.7±8.7. Four cases of stage III all exhibited fairly large PCI (30.4–32.9). In contrast, in 16 cases of stage I the values were spread over a wide range. In 13 cases with histological grade (HG) 1 of stage I, larger PCI were obtained in the nuclear grade (NG) 2 group; the mean PCI values of HG 1‐NG 1 and HG 1‐NG 2 were 16.5 ±4.6 and 25.6±5.2, respectively. Because of the good correlation between PCI and HG or NG, PCI may be useful as an additional prognostic factor in endometrial adenocarcinoma, especially in stage I cases.