Open AccessMulti‐step Carcinogenesis Model for Adult T‐cell Leukemia
Author(s) -
Okarmoto Takashi,
Ohno Yuko,
Tsugane Shoichiro,
Watanabe Shaw,
Shimoyama Masanori,
Tajima Kazuo,
Miwa Masanao,
Shimotohno Kunitada
Publication year - 1989
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1989.tb02289.x
Subject(s) - carcinogenesis , leukemia , weibull distribution , biology , t cell leukemia , virus , cancer research , immunology , medicine , virology , genetics , cancer , mathematics , statistics
The age‐specific occurrence of adult T‐cell leukemia (ATL) was analyzed using 357 cases collected during nationwide surveys carried out between 1982 and 1985 in Japan. A simple Weibull distribution function fitted well as a model. The mode of ATL onset was log‐linear in this model and the curves for males and females overlapped completely. The presence of age‐dependent accumulation of leukemogenic events within human T‐cell leukemia virus type 1‐immortalized T cells was suggested prior to the development of ATL, and the approximate number of independent leukemogenic events in ATL is estimated to be five. This stochastic analysis supported a multi‐step carcinogenesis as an appropriate model for ATL.