Open AccessThe Significance of Low Serum Pepsinogen Levels to Detect Stomach Cancer Associated with Extensive Chronic Gastritis in Japanese Subjects
Author(s) -
Miki Kazumasa,
Ichinose Masao,
Kawamura Norio,
Matsushima Masashi,
Ahmad Haron Bin,
Kimura Masayoshi,
Sano Junjiro,
Tashiro Takao,
Kakei Nobuyuki,
Oka Hiroshi,
Furihata Chie,
Takahashi Kenji
Publication year - 1989
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1989.tb02276.x
Subject(s) - chronic gastritis , pepsin , stomach , gastroenterology , intestinal metaplasia , medicine , stomach cancer , gastritis , cancer , atrophic gastritis , biology , enzyme , biochemistry
Serum pepsinogen levels were measured in 137 stomach cancer patients and compared with those of 288 normal cancer‐free subjects. The serum pepsinogen levels of stomach cancer patients, especially pepsinogen I and the pepsinogen I/pepsinogen II ratio were significantly lower than those of normal controls and correlated well with the extent of chronic gastritis associated with the cancerous stomach. These results were in good accordance with the results of previous studies indicating that the cancer derived from the stomach where chronic gastritis/intestinal metaplasia is extensive. The high sensitivity and specificity of this non‐invasive serum test to detect chronic gastritis suggested the possibility of its application to the mass screening of stomach cancer.