Open AccessMutations of N‐ ras Oncogene in Myelodysplastic Syndromes and Lcukemias Detected by Polymerase Chain Reaction
Author(s) -
Mano Hiroyuki,
Ishikawa Fuyuki,
Hirai Hisamaru,
Takaku Fumimaro
Publication year - 1989
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1989.tb02274.x
Subject(s) - polymerase chain reaction , point mutation , oncogene , mutation , cancer research , biology , haematopoiesis , leukemia , myelodysplastic syndromes , microbiology and biotechnology , gene , genetics , immunology , bone marrow , stem cell , cell cycle
By using polymerase chain reaction and differential hybridization, point mutations of N‐ ras oncogene were investigated among 43 patients with hematopoietic malignancies. Six cases were revealed to carry mutational N‐ ras oncogenes. One case with acute myelocytic leukemia was found to carry a mutation at codon 13, although this case was in complete remission.