Open AccessModulation of Immune Response against Tumor Cells by the in vivo Administration of an Autoreactive Th Clone
Author(s) -
Kubo Masato,
Sano Kunio,
Fujisawa Isao,
Asano Yoshihiro,
Tada Tomio
Publication year - 1989
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1989.tb02266.x
Subject(s) - clone (java method) , biology , immune system , antigen , immunology , population , t cell , t lymphocyte , cytotoxic t cell , cancer research , in vitro , medicine , dna , genetics , environmental health , biochemistry
The immunization of C3H mice with irradiated syngeneic MM48 tumor cells induced specific tumor‐neutralizing cells (TNC). The TNC activity was mediated by the L3T4 + , Ly‐2 − T cell population, and the generation of TNC coincided with the appearance of delayed‐type hypersensitivity response against MM48 antigen. The administration of an auto‐I‐A k reactive T helper cell clone MS202 to normal C3H mice resulted in the facilitation of growth of MM48 tumor due to the induction of T suppressor (Ts) cells. Splenic T cells from animals given this T cell clone inhibited the TNC activity of immunized mice resulting in the escape of MM48 from the TNC effect. The surface phenotype of the Ts cells was L3T4 + , Ly‐2 − . The Ts cells induced by the clone MS202 were totally antigen‐nonspecific, and were able to suppress both the effector and inductive processes of TNC. The results suggest the presence of a physiological MHC‐restricted T cell circuit that regulates immune responses against the growing tumors.