Open AccessHigh Risk of Mother‐to‐Child Transmission of HTLV‐I in p40 tax Antibody‐positive Mothers
Author(s) -
Sawada Takashi,
Tohmatsu Junichi,
Obara Takashi,
Koide Atsushi,
Kamihira Shimeru,
Ichimaru Michito,
Kashiwagi Seizaburo,
Kajiyama Wataru,
Matsumura Nobuyuki,
Kinoshita Kenichiro,
Yano Michitami,
Yamaguchi Kazunari,
Kiyokawa Tetsuyuki,
Takatsuki Kiyoshi,
Taguchi Hirokuni,
Miyoshi Isao
Publication year - 1989
Publication title -
japanese journal of cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 0910-5050
DOI - 10.1111/j.1349-7006.1989.tb01667.x
Subject(s) - antibody , transmission (telecommunications) , virus , virology , enzyme , medicine , viral disease , biology , immunology , biochemistry , electrical engineering , engineering
A new enzyme‐linked immunosorbent assay (ELISA) for detecting the antibody to a human T‐lymphotropic virus type I (HTLV‐I) tax gene product, p40 tax , has been developed. By this ELISA method, we have investigated the relationship between the presence of p40 tax antibody in HTLV‐I‐infected mothers and the virus transmission rate from mothers to their children. The rate of mother‐to‐child transmission of HTLV‐I was higher in P40 tax antibody‐positive mothers than in antibody‐negative ones. Thus, the presence of P40 tax antibody may indicate an increased risk of vertical transmission of HTLV‐I.